4-去甲基异氟烷

中文名称:

4-去甲基异氟烷

中文同义词:

伊曲茶碱杂质14;4-去甲基伊曲茶碱

英文名称:

4-DesMethyl Istradefylline

英文同义词:

4-DesMethyl Istradefylline;(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione;4-DesMethyl Istradefylline impurity;Istradefylline Impurity 14;Istradefylline 4-O-Desmethyl Impurity;1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI);Istradefylline M1 metabolite

CAS号:

160434-48-0

分子式:

C19H22N4O4

分子量:

370.4

EINECS号:

相关类别:

杂质对照品;Aromatics, Heterocycles, Pharmaceuticals, Intermediates Fine Chemicals

Mol文件:

160434-48-0.mol

CAS 数据库

160434-48-0

生物活性

4-Desmethyl Istradefylline 是 Istradefylline 的代谢物。Istradefylline 是一种有效的，选择性的，可口服的 adenosine A2A receptor 拮抗剂，在帕金森疾病模型试验中，Ki 值为 2.2 nM。

用途 

4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.