D-鞘氨醇

中文名称:

D-鞘氨醇

中文同义词:

D-神经鞘氨醇(牛);D-鞘氨醇;D-神经鞘氨醇;D-赤型神经胺;神經胺醇;D-赤-鞘氨醇;(2S,3R,4E)-2-氨基-4-十八碳烯-1,3-二醇;D-赤式-鞘氨醇

英文名称:

D-ERYTHRO-SPHINGOSINE

英文同义词:

SPHINGOSINE;SPHINGOSINE, C18 CHAIN;SPHINGOSINE, D-ERYTHRO;TRANS D-THREO-SPHINGOSINE;TRANS D-ERYTHRO-SPHINGOSINE;TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL;BRAIN SPHINGOSINE;BRAIN, BOVINE

CAS号:

123-78-4

分子式:

C18H37NO2

分子量:

299.49

EINECS号:

204-651-3

相关类别:

原料药;其他科研原料药;脂类;常用糖合成中间体;Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators

Mol文件:

123-78-4.mol

熔点 

74.2-78.1 °C

沸点 

440.8°C (rough estimate)

密度 

0.9758 (rough estimate)

折射率 

1.5000 (estimate)

储存条件 

-20°C

溶解度 

chloroform: 20 mg/mL, clear, colorless to very faintly yellow

形态

Powder or Waxy Solid

酸度系数(pKa)

11.80±0.45(Predicted)

颜色

White to cream

Merck 

14,8747

BRN 

1727294

稳定性

Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

InChIKey

WWUZIQQURGPMPG-KRWOKUGFSA-N

CAS 数据库

123-78-4

生物活性

鞘氨醇，Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine)，是具有不饱和烃链的18个碳原子的氨基醇，它形成鞘脂的主要部分，鞘脂是一类细胞膜脂质，其中包括鞘磷脂，一种重要的磷脂。

靶点

p32 8 μM (EC 50 ) PKC PP2A Human Endogenous Metabolite

p32 8 μM (EC 50 )

PKC

体外研究

A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.

安全说明 

22-24/25

WGK Germany 

3

F 

1-8-10

海关编码 

29221985