他尼氟酯

中文名称:

他尼氟酯

中文同义词:

2-[(3-三氟甲基)苯基]氨基-3-吡啶羧酸苯酞酯;他尼氟酯;氟烟酞酯;氟尼酸酯;酞尼氟酯

英文名称:

Talniflumate

英文同义词:

2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester;3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic;3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl;Talniflumate, >=99%;2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester;2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester;(3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate;ba7602-06

CAS号:

66898-62-2

分子式:

C21H13F3N2O4

分子量:

414.33

EINECS号:

1533716-785-6

相关类别:

生物活性小分子;他尼氟酯及中间体;医用原料

Mol文件:

66898-62-2.mol

熔点 

165-167°C

沸点 

534.6±50.0 °C(Predicted)

密度 

1.49±0.1 g/cm3(Predicted)

储存条件 

Store at +4°C

酸度系数(pKa)

2.72±0.10(Predicted)

最大波长(λmax)

287nm(CHCl3)(lit.)

Merck 

14,9044

生物活性

Talniflumate (MSI-1995)是一种抗炎药，在治疗囊胞性纤维症、慢性阻塞性肺病和哮喘中被用作粘蛋白调节剂。Talniflumate 也是一种人钙激活的氯离子通道chloride channels。

靶点

IC50: Ca 2+ -activated Cl - channel (CaCC)

体内研究

Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction. Animal Model: CF mice with distal intestinal obstructive syndrome (DIOS) Dosage: 0.4 mg/g Administration: Oral chow; 21 days Result: Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Animal Model:

CF mice with distal intestinal obstructive syndrome (DIOS)

Dosage:

0.4 mg/g

Administration:

Oral chow; 21 days

Result:

Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

化学性质 

白色至淡黄色结晶性粉末。

用途 

该品为非甾体消炎镇痛原料药，同时可用于纤维性囊肿和哮喘的辅助治疗。

用途 

为非甾体消炎镇痛药，同时可用于纤维性囊肿和哮喘的辅助治疗

RTECS号

QT2999200

毒性

LD50 orally in rats: 12000 mg/kg (Los)