依泽替米贝去氟代类似物

中文名称:

依泽替米贝去氟代类似物

中文同义词:

依泽替米贝去氟代类似物;去氟依泽替米贝;去氟依折麦布;脱氟依泽替米贝;依折麦布-脱氟苯胺类似物(USP);(3R,4S)-3-((S)-3-(4-氟苯基)-3-羟基丙基)-4-(4-羟基苯基)-1-苯基氮杂环丁烷-2-酮;依折麦布杂质E;去氟依折麦布A

英文名称:

Desfluoro EzetiMibe

英文同义词:

Desfluoro EzetiMibe;(3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenyl-2-azetidinone;1-Desfluoro EzetiMibe;EzetiMibe Desfluoro Analog;(3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one;(3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one;Ezetimibe-5;Ezetimibe impuriry 7/Desfluoro Ezetimibe/(3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one

CAS号:

302781-98-2

分子式:

C24H22FNO3

分子量:

391.43

EINECS号:

相关类别:

对照品-杂质对照品;杂质对照品;医药原料;Impuities;Aromatics;Heterocycles;Inhibitors;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

302781-98-2.mol

沸点 

642.8±55.0 °C(Predicted)

密度 

1.293±0.06 g/cm3(Predicted)

酸度系数(pKa)

9.72±0.30(Predicted)

生物活性

Desfluoro-ezetimibe 是一种 Ezetimibe 的脱氟杂质。Ezetimibe 是一种有效的，代谢稳定的胆固醇吸收抑制剂。Ezetimibe 也是一种 Niemann-Pick C1-like1 (NPC1L1) 抑制剂，还是一种有效的 Nrf2 激活剂。

体外研究

During the synthetic process development studies of Ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chromatography (HPLC) method and its molecular weight is determined by LC–MS analysis. The impurity is Desfluoro-ezetimibe.