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尿石素C

中文名称:
尿石素C
中文同义词:
尿石素C;3,8,9-三羟基-6H-苯并[C]色烯-6-酮
英文名称:
Urolithin C
英文同义词:
3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;Urolithin C;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-
CAS号:
165393-06-6
分子式:
C13H8O5
分子量:
244.2
EINECS号:
相关类别:
对照品;HR140137
Mol文件:
165393-06-6.mol
沸点 
605.4±55.0 °C(Predicted)
密度 
1.640±0.06 g/cm3(Predicted)
储存条件 
Inert atmosphere,Room Temperature
酸度系数(pKa)
7.51±0.20(Predicted)
生物活性
Urolithin C, 是鞣花酸的多酚类肠道微生物代谢产物,是胰岛素分泌 (insulin secretion) 的葡萄糖依赖性激活剂。Urolithin C 是一种 L 型 Ca2+ 通道开放剂,可增强 Ca2+ 的流入。Urolithin C 通过线粒体介导的途径诱导细胞凋亡 (apoptosis),并刺激活性氧 (ROS) 的形成。
靶点
Insulin secretion L-type Ca 2+ channel Reactive oxygen species (ROS) Apoptosis
体外研究
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells. Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis. Urolithin C treatment induces apoptosis and S phase cell cycle arrest. Western Blot Analysis Cell Line: INS-1 cells Concentration: 20 μM, 100 μM Incubation Time: 1 hour Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
Cell Line:
INS-1 cells
Concentration:
20 μM, 100 μM
Incubation Time:
1 hour
Result:
Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
体内研究
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.
CAS号:165393-06-6
规   格:10g/20g/100g/1kg
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英文名:Urolithin C
外观:
纯度:请咨询卖家
分子式:C13H8O5
分子量:244.2
最小起售量:10g/20g/100g/1kg
中文名称:
尿石素C
中文同义词:
尿石素C;3,8,9-三羟基-6H-苯并[C]色烯-6-酮
英文名称:
Urolithin C
英文同义词:
3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;Urolithin C;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-
CAS号:
165393-06-6
分子式:
C13H8O5
分子量:
244.2
EINECS号:
相关类别:
对照品;HR140137
Mol文件:
165393-06-6.mol
沸点 
605.4±55.0 °C(Predicted)
密度 
1.640±0.06 g/cm3(Predicted)
储存条件 
Inert atmosphere,Room Temperature
酸度系数(pKa)
7.51±0.20(Predicted)
生物活性
Urolithin C, 是鞣花酸的多酚类肠道微生物代谢产物,是胰岛素分泌 (insulin secretion) 的葡萄糖依赖性激活剂。Urolithin C 是一种 L 型 Ca2+ 通道开放剂,可增强 Ca2+ 的流入。Urolithin C 通过线粒体介导的途径诱导细胞凋亡 (apoptosis),并刺激活性氧 (ROS) 的形成。
靶点
Insulin secretion L-type Ca 2+ channel Reactive oxygen species (ROS) Apoptosis
体外研究
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells. Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis. Urolithin C treatment induces apoptosis and S phase cell cycle arrest. Western Blot Analysis Cell Line: INS-1 cells Concentration: 20 μM, 100 μM Incubation Time: 1 hour Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
Cell Line:
INS-1 cells
Concentration:
20 μM, 100 μM
Incubation Time:
1 hour
Result:
Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.
体内研究
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.
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