MRS-1845;MRS1845;MRS 1845

中文名称:

MRS-1845;MRS1845;MRS 1845

中文同义词:

英文名称:

MRS 1845

英文同义词:

N-PROPARGYLNITRENDIPENE;MRS 1845;1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-1-(2-PROPYNYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL, METHYL ESTER;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylicacidethylmethylester;MRS-1845;MRS1845;MRS 1845;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propyn-1-yl)-, 3-ethyl 5-methyl ester;MRS 1845 >=95% (HPLC), solid

CAS号:

544478-19-5

分子式:

C21H22N2O6

分子量:

398.41

EINECS号:

相关类别:

Calcium channel;API

Mol文件:

544478-19-5.mol

沸点 

511.0±50.0 °C(Predicted)

密度 

1.238±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

DMSO: 13 mg/mL at 60 °C, soluble

形态

solid

酸度系数(pKa)

0.03±0.70(Predicted)

颜色

yellow

生物活性

MRS1845 是一种选择性钙池调控钙离子通道 (SOC) 抑制剂，IC50 为 1.7 μM。MRS1845 是一种 ORAI1 抑制剂。

靶点

Ca 2+ channel

体外研究

Treatment with MRS1845 (10 μM) virtually disrupts the effects of β-glycerophosphate on store-operated Ca 2+ entry (SOCE). MRS1845 (10 μM) significantly decreases SOCE and virtually abolishes the increase of SOCE following placental growth factor (PlGF) treatment.

WGK Germany 

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