毒蠅虎蕈鹼

中文名称:

毒蠅虎蕈鹼

中文同义词:

伞毒素, 来源于鬼笔鹅膏;鬼笔环肽*CAS#: 17466-45-4*;二羟鬼笔毒肽;毒蠅虎蕈鹼;鬼笔环肽 来源于鬼笔鹅膏;鬼笔环肽;毒伞素

英文名称:

PHALLOIDIN

英文同义词:

Phalloidin, Amanita phalloides - CAS 17466-45-4 - Calbiochem;Phalloidin trifluoroacetate salt;pto-l-tryptophyl-4,5-dihydroxy-l-leucyl),cyclic(3,6)-sulfide;PHALLOIDIN;PHALLOIDIN, AMANITA PHALLOIDES;PHALLOIDIN FROM AMANITA PHALLOIDES;Cyclo(L-Ala-D-Thr-L-Cys(1)-L-c4Hyp-L-Ala-L-Trp2(1)-4,5-dihydroxy-L-Leu-);Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3.fwdarw.6)-sulfide

CAS号:

17466-45-4

分子式:

C35H48N8O11S

分子量:

788.87

EINECS号:

241-484-5

相关类别:

荧光探针，标记，颗粒和染色;marker

Mol文件:

17466-45-4.mol

熔点 

280-282°

比旋光度 

+55.7°(D/20℃)(c=0.5,メタノール)

密度 

1.1612 (rough estimate)

折射率 

1.7400 (estimate)

储存条件 

+2C to +8C

形态

White crystalline solid

沸点 

1370.5±65.0 °C(Predicted)

酸度系数(pKa)

13.03±0.70(Predicted)

颜色

Hexahydrate, needles or crystals from water

Merck 

13,7273

BRN 

4347460

稳定性

Stable. Incompatible with strong oxidizing agents.

生物活性

Phalloidin 是一种蘑菇衍生的毒素，可以与荧光染料结合来标记细胞骨架的 F-肌动蛋白 (λex=495 nm， λem=520 nm)。

体外研究

Phalloidin staining will not work with methanol-fixed cells, probably because of the disruption of actin filament integrity, but it will work with cells fixed in 0.2% glutaraldehyde in PBS. For fluorescein isothiocyanate (FITC)-Phalloidin (or rhodamine isothiocyanate [RITC]-Phalloidin), the excitation wavelength maximum will be near 495 nm (or 550 nm) and the emission wavelength maximum will be ~520 nm based on H 2 O at pH 8.0 as the solvent (575 nm with methanol as the solvent). The emission spectrum of fluorescein can depend on the environmental pH and/or ionic strength.

类别

有毒物质

毒性分级

剧毒

急性毒性

腹腔- 大鼠 LD50: 1 毫克/ 公斤; 腹腔- 小鼠 LD50: 2 毫克/ 公斤

可燃性危险特性

可燃, 燃烧时分解有毒硫氧化物和氮氧化物气体

储运特性

库房低温, 通风, 干燥; 与食品原料分开存放

灭火剂

水, 二氧化碳, 干粉, 砂土

危险品标志 

T+

危险类别码 

26/27/28

安全说明 

22-28-36/37-45

危险品运输编号 

UN 3462 6.1/PG 2

WGK Germany 

3

RTECS号

SE9800000

F 

18

HazardClass 

6.1(a)

PackingGroup 

I

毒性

LD50 i.m. in albino mice: 3.3 mg/g (Vogt); LD50 i.p. in mice: 2 mg/kg (Wieland, Wieland)