益母草碱单盐酸盐

中文名称:

益母草碱单盐酸盐

中文同义词:

盐酸益母草碱(益母草碱盐酸盐);益母草碱单盐酸盐

英文名称:

4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride

英文同义词:

4-Hydroxy-3,5-dimethoxybenzoic acid 4-[(aminoiminomethyl)amino]butyl ester monohydrochloride;Leonurin monohydrochloride;4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride;SCM-198 hydrochloride;SCM-198 HCl

CAS号:

24735-18-0

分子式:

C14H22ClN3O5

分子量:

347.79458

EINECS号:

相关类别:

标准品

Mol文件:

24735-18-0.mol

熔点 

194℃

储存条件 

Sealed in dry,Room Temperature

生物活性

Leonurine hydrochloride 是从 Herba leonuri 中分离到的生物碱，具有抗氧化、抗炎活性。

体外研究

Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

体内研究

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

化学性质 

白色结晶粉末，易溶于甲醇、水，来源于益母草Leonurus artemisia (Laur.) S. Y. Hu F。

用途 

盐酸益母草碱具有活血、祛淤、调经、消水的作用。