印枳碱

中文名称:

印枳碱

中文同义词:

印枳碱;N-[2-羟基-2-(4-甲氧基苯基)乙基]肉桂酰胺

英文名称:

Aegelin

英文同义词:

(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide;N-(2-Hydroxy-2-(4-Methoxyphenyl)ethyl)cinnaMaMide;Aegeline;Aegeline,N-[2-hydroxy-2(4-Methoxyphenyl) ethyl]-3-phenyl-2-propenaMide;Aegelin;N-CinnaMoyl-β-hydroxy-4-Methoxyphenyl-aethylaMin;2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-;(E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide

CAS号:

456-12-2

分子式:

C18H19NO3

分子量:

297.35

EINECS号:

1533716-785-6

相关类别:

保健品添加剂;中药对照品

Mol文件:

456-12-2.mol

熔点 

178-179℃

储存条件 

Inert atmosphere,2-8°C

用途

印枳碱为芳香类衍生物，其可用作医药合成中间体。

生物活性

Aegeline 是一种主要生物碱，模拟酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突触核蛋白和 Bax 毒性。Aegeline 恢复 αsyn 或 Bax 抑制的酵母细胞生长。

体外研究

Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells. Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.