1370046-40-4

中文名称:

1370046-40-4

中文同义词:

英文名称:

SSE15206

英文同义词:

SSE15206;SSE-15206;SSE 15206;SSE15206; SSE-15206; SSE 15206;1370046-40-4;1H-Pyrazole-1-carbothioamide, 4,5-dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-;4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide;3-Phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

CAS号:

1370046-40-4

分子式:

C19H21N3O3S

分子量:

371.45

EINECS号:

相关类别:

API

Mol文件:

1370046-40-4.mol

沸点 

518.7±60.0 °C(Predicted)

密度 

1.27±0.1 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

14.12±0.60(Predicted)

生物活性

SSE15206 是一种微管 (microtubule) 聚合抑制剂，其在 HCT116 细胞中的 GI50 值为 197 nM，能克服多重耐药性。引起细胞中纺锤体形成不完全，从而导致 G2/M 阻滞，有丝分裂异常。

靶点

GI50: 197 nM (microtubule).

体外研究

SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 × and 10 × GI 50 values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines. Western Blot Analysis Cell Line: Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells. Concentration: 5 × and 10 × GI 50 values (GI 50 =197 nM in HCT-116 cells). Incubation Time: 24 hours. Result: Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.

Cell Line:

Drug-resistant cell lines (KB-V1, A2780-Pac-Res, HCT116-Pac-Res) and parental cells.

Concentration:

5 × and 10 × GI 50 values (GI 50 =197 nM in HCT-116 cells).

Incubation Time:

24 hours.

Result:

Induced apoptosis in cells irrespective of MDR-1 overexpression and HCT116-Pac-Res and parental cells.