阿托伐他汀杂质L

中文名称:

阿托伐他汀杂质L

中文同义词:

阿托伐他汀环氧四氢呋喃类似物;阿托伐他汀环氧四氢呋喃杂质;阿托伐他汀钙环氧四氢呋喃类似物;阿托伐他汀杂质L;阿托伐他汀环氧四氢呋喃类似物(USP);阿托伐他汀四氢呋喃类似物;阿托伐他汀环氧四氢呋喃类似物对照品;阿托伐他汀四氢呋喃环氧杂质

英文名称:

Atorvastatin Epoxy Tetrahydrofuran IMpurity

英文同义词:

Atorvastatin Epoxy Tetrahydrofuran IMpurity;4-(4-fluorophenyl)-2,4-dihydroxy-N,5-diphenyl-2-propan-2-yl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide;Atorvastatin Epoxy Tetrahydrofuraran analog;4-(4-fluorophenyl)-2,4-dihydroxy;Atorvastatin impurity 28/Atorvastatin Epoxy Tetrahydrofuran Impurity/4-(4-Fluorophenyl)-2,4-dihydroxy-2-(1-methylethyl)-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide;Atorvastatin epoxy tetrahydrofuran;4-(4-Fluorophenyl)-2,4-dihydroxy-2-(1-Methylethyl)-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxaMide;Atorvastatin Photo Degradation Product

CAS号:

873950-19-7

分子式:

C26H24FNO5

分子量:

449.47

EINECS号:

相关类别:

杂质对照品;对照品-杂质对照品;杂质;标准品;阿托光照降解杂质;Amines;Aromatics;Chiral Reagents;Impurities;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

873950-19-7.mol

沸点 

661.1±55.0 °C(Predicted)

密度 

1.435±0.06 g/cm3(Predicted)

酸度系数(pKa)

10.43±0.70(Predicted)

生物活性

Atorvastatin Epoxy Tetrahydrofuran Impurity 是阿托伐他汀 (Atorvastatin；HY-B0589) 氧化降解产物的一种杂质。Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。

体外研究

Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.