ML241 (hydrochloride)

中文名称:

ML241 (hydrochloride)

中文同义词:

P97ATPASE抑制剂(ML241 HYDROCHLORIDE);化合物ML241 HYDROCHLORIDE

英文名称:

ML241 (hydrochloride)

英文同义词:

ML241 (hydrochloride)

CAS号:

2070015-13-1

分子式:

C23H25ClN4O

分子量:

0

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

Mol File

生物活性

ML241 hydrochloride 是一种 p97 的有效选择性抑制剂，对 p97 ATPase 和 UbG76V–GFP 的IC50值分别为0.11 μM和3.5 μM。

靶点

Target Value p97 ATPase (Cell-free assay) 0.11 μM Ub (Cell-free assay) 3.5 μM

Target

Value

p97 ATPase (Cell-free assay)

0.11 μM

Ub (Cell-free assay)

3.5 μM

体外研究

ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K i values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub G76V -GFP with IC 50 of 3.5 μM. ML241 is cytotoxic to HCT15 and SW403 cells, with GI 50 s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively.