GS0976,ND-630

中文名称:

GS0976,ND-630

中文同义词:

1,4-二氢-1-[(2R)-2-(2-甲氧基苯基)-2-[(四氢-2H-吡喃-4-基)氧基]乙基]-Α,Α,5-三甲基-6-(2-恶唑基)-2,4-二氧噻吩并[2,3-D]嘧啶-3(2H)-乙酸

英文名称:

NDI-010976

英文同义词:

NDI-010976;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;ND-630;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid;EOS-61252;GS0976;CPDB5078;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-

CAS号:

1434635-54-7

分子式:

C28H31N3O8S

分子量:

569.63

EINECS号:

相关类别:

API

Mol文件:

1434635-54-7.mol

沸点 

779.0±70.0 °C(Predicted)

密度 

1.42±0.1 g/cm3(Predicted)

酸度系数(pKa)

3.66±0.10(Predicted)

生物活性

Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM。

靶点

Target Value hACC1 (Cell-free assay) 2.1 nM hACC2 (Cell-free assay) 6.1 nM

Target

Value

hACC1 (Cell-free assay)

2.1 nM

hACC2 (Cell-free assay)

6.1 nM