H-LEU-ARG-PRO-OH

中文名称:

H-LEU-ARG-PRO-OH

中文同义词:

L-亮氨酰-L-精氨酰-L-脯氨酸

英文名称:

H-LEU-ARG-PRO-OH

英文同义词:

LHRH (7-9) SEQUENCE 2HCL;H-LEU-ARG-PRO-OH;H-LEU-ARG-PRO-OH 2HCL;LHRH 7-9 SEQUENCE;Leu-Arg-Pro;LRP;Leucylarginylproline;L-Proline,L-leucyl-L-arginyl-

CAS号:

133943-59-6

分子式:

C17H32N6O4

分子量:

384.47

EINECS号:

相关类别:

Mol文件:

133943-59-6.mol

密度 

1.39±0.1 g/cm3(Predicted)

储存条件 

-15°C

酸度系数(pKa)

3.39±0.20(Predicted)

生物活性

Leucylarginylproline是血管紧张素转换酶 (ACE) 抑制剂，IC50值为0.27μM。

靶点

IC50: 0.27μM (ACE)

体外研究

Intravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration.