九聚精氨酸

中文名称:

九聚精氨酸

中文同义词:

九聚精氨酸;POLY ARGININE 9;(ARG)9游离态

英文名称:

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

英文同义词:

H-RRRRRRRRR-NH2;RRRRRRRRR;(ARG)9;H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH;Nonaarginine;H(-Arg)9-OH, Nonaarginine;(Arg)9 peptide;Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

CAS号:

143413-47-2

分子式:

C54H110N36O10

分子量:

1423.69

EINECS号:

相关类别:

肽类中间体;多肽;peptide

Mol文件:

143413-47-2.mol

密度 

1.60±0.1 g/cm3(Predicted)

生物活性

(Arg)9 (Nona-L-arginine;Peptide R9)是可渗透细胞的多肽，在谷氨酸模型实验模型中保护神经的IC50值为0.78 μM。

靶点

IC50: 0.78 μM (neuroprotection)

体外研究

Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).

体内研究

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.