NE 10790

中文名称:

NE 10790

中文同义词:

化合物NE 10790

英文名称:

NE 10790

英文同义词:

3-PEHPC;NE 10790;FJVYPXVLXQXDHM-UHFFFAOYSA-N;NE 10790 (Synonyms: 3-PEHPC);NE 10790 (3-PEHPC);2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid;3-Pyridinepropanoic acid, α-hydroxy-α-phosphono-

CAS号:

152831-36-2

分子式:

C8H10NO6P

分子量:

247.14

EINECS号:

相关类别:

API

Mol文件:

152831-36-2.mol

沸点 

583.6±60.0 °C(Predicted)

密度 

1.724±0.06 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)

1.73±0.10(Predicted)

生物活性

NE 10790 是法尼焦磷酸 (FPP) 合成酶的弱抑制剂，是有效的二磷酸利塞磷酸盐的磷酸酯类似物，也是一种弱的抗吸收剂。

靶点

FPP synthase.

体外研究

NE 10790 inhibits incorporation of [ 14 C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I.