1354707-41-7

中文名称:

1354707-41-7

中文同义词:

4-(2,4-二氟苯基)-2-(1H-吲哚-3-基)-4-氧代丁酸

英文名称:

Mitochonic acid 5

英文同义词:

Mitochonic acid 5;Mitochonic acid;1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-;Mitochonic acid 5(MA-5);α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid

CAS号:

1354707-41-7

分子式:

C18H13F2NO3

分子量:

329.3

EINECS号:

相关类别:

API

Mol文件:

Mol File

沸点 

573.3±50.0 °C(Predicted)

密度 

1.426±0.06 g/cm3(Predicted)

酸度系数(pKa)

4.52±0.37(Predicted)

生物活性

Mitochonic acid 5 (MA-5) 可通过上调 mitophagy 线粒体自噬来降低线粒体的凋亡。Mitochonic acid 5 可通过Bnip3和 MAPK-ERK-Yap 信号通路来调节线粒体自噬。Mitochonic acid 5 可调节线粒体的ATP的合成。

靶点

Target Value mitophagy () Bnip3 ()

Target

Value

mitophagy ()

Bnip3 ()

体外研究

Mitochonic acid 5 (MA-5) modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases. Mitochonic acid 5 (MA-5), which is derived from the plant growth hormone indole-3-acetic acid, can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. To observe the protective role of Mitochonic acid 5 in microglia under inflammatory conditions, TNFα is applied. Subsequently, the MTT assay is used to evaluate cell viability. In response to the TNFα treatment, cell viability significantly decreases. However, this effect is dose-dependently inhibited by Mitochonic acid 5 treatment.

体内研究

Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour.