丹參酸B鎂

中文名称:

丹參酸B鎂

中文同义词:

丹參酸B鎂;丹参酸 B 镁盐;丹参酚酸B甲酯

英文名称:

MAGNESIUM LITHOSPERMATE B 98%

英文同义词:

MAGNESIUM LITHOSPERMATE B 98%;Monomethyl lithospermate B;magnessium lithospermate B;magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate

CAS号:

122021-74-3

分子式:

C36H28MgO16

分子量:

740.90292

EINECS号:

相关类别:

标准品;标准品-中药标准品;标准品 -中药标准品;标准品-对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

122021-74-3.mol

生物活性

Magnesium Lithospermate B 是从 Salviae miltiorrhizae 中提取的咖啡酸四聚体的衍生物。Magnesium Lithospermate B 被广泛用于心血管疾病的研究，并且可以防止葡萄糖引起的细胞内氧化损伤。Magnesium Lithospermate B 还能够抑制神经炎症并减轻神经变性。

体外研究

Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis. Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner. Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons.

体内研究

Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats. Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models. Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats Dosage: 2, 8 mg/kg Administration: P.o. once daily for 16 days Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.

Animal Model:

Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats

Dosage:

2, 8 mg/kg

Administration:

P.o. once daily for 16 days

Result:

Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21.