富马酸单甲酯

中文名称:

富马酸单甲酯

中文同义词:

富马酸单甲酯;富马酸单甲酯, 97%+;富马酸单甲基酯;富马酸单甲酯 5G;MONOMETHYL FUMARATE英文同义词: (E)-2-BUTENEDIOIC ACID HYDROGEN 1-METHYL ESTER;富马酸单甲酯(CAS号:2756-87-8);富马酸单甲酯 标准品;(E)-4-甲氧基-4-氧代丁基-2-烯酸

英文名称:

Monomethyl fumarate

英文同义词:

(E)-2-Butenedioic acid hydrogen 1-methyl ester;Fumaric acid hydrogen 1-methyl ester;Monomethyl trans-ethylene-1,2-dicarboxylate;Monomethyl fumarate;Methyl hydrogen fumarate;Fumaric acid monomethyl ester;mono-Methyl fumarate,Fumaric acid monomethyl ester, Methyl hydrogen fumarate;(2E)-4-Methoxy-4-oxobut-2-enoic acid

CAS号:

2756-87-8

分子式:

C5H6O4

分子量:

130.1

EINECS号:

220-412-6

相关类别:

羰基化合物;酯;杂质对照品;原料;食品添加剂;杀菌防腐剂;有机化工原料;防腐剂;有机中间体;化工原料;其他原料;化工材料

Mol文件:

2756-87-8.mol

熔点 

144-145 °C (lit.)

沸点 

250.0±23.0 °C(Predicted)

密度 

1.37 g/cm3

储存条件 

2-8°C

酸度系数(pKa)

3.40±0.10(Predicted)

最大波长(λmax)

209nm(MeOH)(lit.)

CAS 数据库

2756-87-8(CAS DataBase Reference)

生物活性

Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate) 是牛皮癣药物Fumaderm的活性代谢产物，是一种有效的 GPR109A 的激动剂。Monomethyl Fumarate 可预防与神经退行性疾病相关的主要功能障碍：氧化应激、线粒体功能障碍、凋亡和自噬。

靶点

Target Value GPR109A ()

Target

Value

GPR109A ()

体外研究

Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC 50 of 70 nM. Monomethyl fumarate induces a dose-dependent Ca 2+ signal in GPR109A transfected cells with an EC 50 of 9.4 μM. Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.

体内研究

A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α. Animal Model: Albino BALB/c mice (male, 6 weeks old) Dosage: 50, 65, 75, 100 mg/kg Administration: IP Result: Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.

Animal Model:

Albino BALB/c mice (male, 6 weeks old)

Dosage:

50, 65, 75, 100 mg/kg

Administration:

IP

Result:

Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.

用途 

用作饲料防霉剂

危险品标志 

Xi

危险类别码 

41

安全说明 

26-39

WGK Germany 

3

海关编码 

29171900