1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000

中文名称:

1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000

中文同义词:

DMG-PEG2000阳离子脂质体;DMG-PEG2000长循环脂质体;ONPATTRO磷脂DMG-PEG2000;1,2-二肉豆蔻酰基-SN-甘油-3-甲氧基聚乙二醇;1,2-二肉豆蔻酰-RAC-甘油-3-甲氧基聚乙二醇2000

英文名称:

DMG-PEG 2000

英文同义词:

DMG-PEG 2000;1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000;1,?2-?Dimyristoyl-?sn-?glycero-?3-?methoxypolyethylene glycol;Polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG];Methoxypoly(ethylene glycol) dimyristoyl glycerol

CAS号:

160743-62-4

分子式:

分子量:

0

EINECS号:

相关类别:

蔗糖（供注射用）;阳离子脂质;新冠疫苗辅料

Mol文件:

Mol File

生物活性

DMG-PEG 2000 用于 siRNA 转染 (siRNA delivery) 的脂质体的制备，能够提高转染效率。DMG-PEG 2000 也可被用于脂质纳米颗粒制备，用于口服质粒 DNA 的体内传递途径，DMG-PEG 2000 可以提高纳米颗粒的黏液渗透性和传递效率。

体外研究

NP-3 (0.05-1.6 mg/mL; 24 hours) does not decrease the cytotoxicity of cells in 293T, HepG2, A549, and HeLa cell lines, but the DPPC and DMG-PEG coated nanoparticles reduce cell cytotoxicity. In addition, the transfection efficiency of DPPC/DMG-PEG/(lPEI/DNA) nanoparticles (NP-3) in 293 cells is improved, and the maximum transfection efficiency (∼76% eGFP positive cells) is observed.

体内研究

NP-3 (oral administration; 150 μg DNA per mouse; single dose) at 12, 24, and 36 h postadministration, luciferin substrate is intraperitoneally injected to verify its permeability. NP-3 group maintains high luciferase expression in the liver, lung, and intestine areas 12-24 h post-treatment.Additionally, NP-3 exhibits 1.5 times higher signal intensity than that of NP-1 or NP-2 group from 12 to 24 h postoral administration.