雷莫拉宁

中文名称:

雷莫拉宁

中文同义词:

雷莫拉宁复合物;雷莫拉宁

英文名称:

Ramoplanin

英文同义词:

A 16686;A 16686A;Antibiotic A 16686;RaMoplanin(A 16686,A 16686A);RaMoplanin coMplex;Ramoplanin;Ramoplaninr

CAS号:

76168-82-6

分子式:

C106H170ClN21O30

分子量:

2254.0597

EINECS号:

相关类别:

医药原料药;微生物代谢物;医药原料;医药原料;医用原料;原料药

Mol文件:

76168-82-6.mol

熔点 

210-230°

比旋光度 

D20 +78.3° (c = 1.04 in H2O)

储存条件 

?20°C

溶解度 

H2O: soluble10mg/mL

形态

powder

InChIKey

FSBZBQUUCNYWOK-KFTDLNJOSA-N

生物活性

Ramoplanin 是一种源于 Actinoplanes spp 的糖肽类抗生素，具有抗革兰氏阳性菌活性。

靶点

Bacteria

体外研究

Ramoplanin exerts its bactericidal activity against gram-positive aerobic and anaerobic bacteria by blocking peptidoglycan synthesis via lipid II.

体内研究

Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level during treatment. Animal Model: Female CF1 mice (25-30 g) Dosage: 100 μg/ml, 500 μg/ml Administration: Oral administration; for 8 days Result: Developed undetectable levels of VRE in stool during treatment.

Animal Model:

Female CF1 mice (25-30 g)

Dosage:

100 μg/ml, 500 μg/ml

Administration:

Oral administration; for 8 days

Result:

Developed undetectable levels of VRE in stool during treatment.

危险品标志 

Xi

危险类别码 

41

安全说明 

26-39

WGK Germany 

nwg

RTECS号

VE5050000

毒性

LD50 in mice (mg/kg): 328 i.p., 122 i.v.; orally in rats: 2000 mg/kg (Pallanza)