中文名称:

1802977-61-2

中文同义词:

LDHA抑制剂(GNE-140 RACEMATE);3-((2-氯苯基)硫代)-6-(4-吗啉代苯基)-6-(噻吩-3-基)哌啶-2,4-二酮

英文名称:

GNE-140 (racemate)

英文同义词:

GNE-140 racemate (GNE 140 racemate;GNE-140 (racemate);3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione;2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-

CAS号:

1802977-61-2

分子式:

C25H23ClN2O3S2

分子量:

499.04

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1802977-61-2.mol

沸点 

739.0±60.0 °C(Predicted)

密度 

1.43±0.1 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

9.61±0.70(Predicted)

生物活性

GNE-140 racemate 是一种 (R)-GNE-140 和 (S)-GNE-140 的外消旋混合物。GNE-140 racemate 也是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂。

靶点

Lactate dehydrogenase A (LDHA)

体外研究

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion.