钩吻碱
中文名称:
钩吻碱
中文同义词:
常绿黄素馨碱;钩吻素甲;钩吻碱钾;钩吻碱;胡曼鹼;钩吻素甲,钩吻碱钾,胡曼鹼,常绿黄素馨碱;钩吻素甲(标准品);钩吻碱, 来源于胡蔓藤
英文名称:
GELSEMINE
英文同义词:
(3r-(3alpha,4abeta,5alpha,8alpha,8abeta,9s*,10s*))-5-ethenyl-3,4,4a,5,6,7,8,8a;[3R-(3alpha,4abeta,5alpha,8alpha,8abeta,9S*,10S*)]-5-Etheny l-3,4,4a,5,6,7,8,8a-octahydro-7-methylspiro[3,5,8-ethanylylidene-1H-p yrano[3,4-c]pyridine-10,3-[3H]indol]-2(1H)-one;3h)indol)-2’(1’,h)-one;8abeta,9s*,10s*))-8alph;Gelsemin;ne,5-ethenyl-3,4,4a,5,6,7,8,8a-octahydro-7-methyl-,(3r-(3alpha,4abeta,5alpha,;-octahydro-7-methylspiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(;spiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(3h)indol)-2’(1’h)-o
CAS号:
509-15-9
分子式:
C20H22N2O2
分子量:
322.4
EINECS号:
208-095-2
相关类别:
植提标准品;对照品;中药对照品;标准品;植物提取物;分析试剂标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Alkaloids;新品;生物碱;标准品 -中药标准品;标准品，对照品
Mol文件:
509-15-9.mol
熔点
181-183°C
比旋光度
D20 +13° (c = 1.2 in chloroform)
沸点
461.02°C (rough estimate)
密度
1.1478 (rough estimate)
折射率
1.5700 (estimate)
储存条件
Sealed in dry,2-8°C
酸度系数(pKa)
7.75 in 80% methylcellosolve
生物活性
Gelsemine 是一种来自中草药 Gelsemium elegans 的生物碱，可有效减轻慢性疼痛。具有抗伤害和催眠作用。
体内研究
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
化学性质
白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于断肠草、葫蔓藤科植物葫蔓藤钩吻。
用途
钩吻碱具有抗癌镇痛的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:具有兴奋中枢神经作用，但毒性很大。
类别
有毒物质
毒性分级
高毒
急性毒性
腹腔-小鼠 LD50: 49 毫克/公斤
可燃性危险特性
可燃; 火场分解有毒氮氧化物烟雾
储运特性
库房低温, 通风, 干燥; 与食品原料分开存放
灭火剂
水, 二氧化碳, 干粉, 砂土
危险品标志
T+
危险类别码
23/24/25-26/27/28
安全说明
36/37/39-45-28
危险品运输编号
UN 1544 6.1/PG 2
WGK Germany
3
RTECS号
LX9100000
HazardClass
6.1(a)
PackingGroup
I
