8-O-乙酰山栀苷甲酯
中文名称:
8-O-乙酰山栀苷甲酯
中文同义词:
8-O-ACETYL SHANZHISIDE METHYL ESTER 8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯(标准品);8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯, 来源于独一味;8-O-乙酰山栀苷甲酯, >98%
英文名称:
8-O-acetyl shanzhiside methyl ester
英文同义词:
(1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester;Barlerin;O-Acetyl Shanzhiside Methyl Ester, 8-;8-Acetylshanzhiside Methyl ester;UMbroside;8-O-Acetyl shanzhiside methyl ester, 98%, from Lamiophlomis rotata (Benth. ex Hook.f.) Kud
CAS号:
57420-46-9
分子式:
C19H28O12
分子量:
448.42
EINECS号:
相关类别:
分析试剂标准品;中药对照品;标准品;植物提取物;对照品;植提标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品 -中药标准品;环烯醚萜;标准品，对照品
Mol文件:
57420-46-9.mol
沸点
634.2±55.0 °C(Predicted)
密度
1.52
酸度系数(pKa)
12.80±0.70(Predicted)
生物活性
Barlerin (8-O-Acetyl shanzhiside methyl ester) 是从中国西藏民间药用植物中分离出的环孢菌素葡萄糖苷。Barlerin (8-O-Acetyl shanzhiside methyl ester) 可以抑制 NF-κB 活性。
靶点
Target Value
NF-κB
()
Target
Value
NF-κB
()
体外研究
Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. . Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.
体内研究
Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice.
化学性质
类白色结晶粉末，易溶于甲醇乙醇，来源于独一味。
用途
8-O-乙酰山栀苷甲酯具有止血镇痛的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:有活化淤血、 止痛止血。
安全说明
24/25
海关编码
29389090
