地榆皂苷I
中文名称:
地榆皂苷I
中文同义词:
苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I;苦丁冬青甙 H;地榆皂苷I;苦丁冬青苷H;地榆皂苷I(标准品);苦丁冬青甙 I;地榆皂苷I(苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I);地榆糖苷I)
英文名称:
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
英文同义词:
Ulmus pumila saponin I;3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester;Kudinoside H;Zigu-glucoside I;Gouguside 7;Ziyu-glycoside Ⅰ;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-
CAS号:
35286-58-9
分子式:
C41H66O13
分子量:
766.95
EINECS号:
相关类别:
分析试剂标准品;对照品;中药对照品;标准品;植物提取物;植提标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品 -中药标准品;三萜;标准品，对照品
Mol文件:
35286-58-9.mol
熔点
198-202 ºC
沸点
841.9±65.0 °C(Predicted)
密度
1.35
酸度系数(pKa)
12.52±0.70(Predicted)
概述
地榆皂苷I，英文名ziyu-glycoside I，是从蔷薇科地榆属植物地榆或长叶地榆的根中提取得到的有明显药理活性的化合物。
生物活性
Ziyuglycoside I 从 S. officinalis 根中分离，具有抗皱活性，并增加 I 型胶原蛋白的表达。 Ziyuglycoside I 可用作化妆品的有效成分。Ziyuglycoside I 引发 p53 介导的细胞周期阻滞和凋亡 (apoptosis)，可用于三阴乳腺癌的相关研究。
体外研究
Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 µM in MDA-MB-231 cells. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.
Cell Viability Assay
Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM
Incubation Time: 24 hours
Result: Showed cytotoxicity on MDA-MB-231 cells.
Cell Cycle Analysis
Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, and 20 µM
Incubation Time: 24 hours
Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells
Western Blot Analysis
Cell Line: MDA-MB-231 cells
Concentration: 5 µM, 10 µM, and 20 µM
Incubation Time: 24 hours
Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.
Cell Line:
MDA-MB-231 cells
Concentration:
5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM
Incubation Time:
24 hours
Result:
Showed cytotoxicity on MDA-MB-231 cells.
Cell Line:
MDA-MB-231 cells
Concentration:
5 µM, 10 µM, and 20 µM
Incubation Time:
24 hours
Result:
Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells
Cell Line:
MDA-MB-231 cells
Concentration:
5 µM, 10 µM, and 20 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.
化学性质
白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于地榆。
用途
地榆皂苷Ⅰ具有收缩血管，止血，抗真菌的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:具有一定的保肝利胆效果。
