地榆皂苷Ⅱ
中文名称:
地榆皂苷Ⅱ
中文同义词:
地榆皂苷 II;地榆皂苷II(标准品);地榆甙II;地榆皂苷LL;地榆皂苷II对照品,;地榆皂苷II、地榆苷Ⅱ
英文名称:
Ziyuglycoside II
英文同义词:
Ziyuglycoside II;(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Zigu-glucoside II;Gouguside 1;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-;Ziyuglycoside;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci
CAS号:
35286-59-0
分子式:
C35H56O8
分子量:
604.83
EINECS号:
相关类别:
分析试剂标准品;中药对照品;标准品;植物提取物;对照品;植提标准品;标准品-中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;三萜;标准品，对照品
Mol文件:
35286-59-0.mol
熔点
260-263℃
沸点
716.2±60.0 °C(Predicted)
密度
1.25
酸度系数(pKa)
4.47±0.70(Predicted)
生物活性
Ziyuglycoside II 是从 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 诱导活性氧 (ROS) 产生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。
体外研究
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC 50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
Cell Line: MDA-MB-435 cells
Concentration: 10, 20, 30, 40, 50, 60 μM
Incubation Time: 24 hours and 48 hours
Result: The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively.
Cell Cycle Analysis
Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: Induced G0/G1 and S phase arrest.
Apoptosis Analysis
Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: The apoptotic rate was significantly increased in comparison to that of the control.
Western Blot Analysis
Cell Line: MDA-MB-435 cells
Concentration: 5, 10, 25 μM
Incubation Time: 24 hours
Result: Treatment resulted in increased expressions of both p53 and p21.
Cell Line:
MDA-MB-435 cells
Concentration:
10, 20, 30, 40, 50, 60 μM
Incubation Time:
24 hours and 48 hours
Result:
The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively.
Cell Line:
MDA-MB-435 cells
Concentration:
5, 10, 25 μM
Incubation Time:
24 hours
Result:
Induced G0/G1 and S phase arrest.
Cell Line:
MDA-MB-435 cells
Concentration:
5, 10, 25 μM
Incubation Time:
24 hours
Result:
The apoptotic rate was significantly increased in comparison to that of the control.
Cell Line:
MDA-MB-435 cells
Concentration:
5, 10, 25 μM
Incubation Time:
24 hours
Result:
Treatment resulted in increased expressions of both p53 and p21.
化学性质
白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于地榆。
用途
地榆皂苷Ⅱ具有收缩血管，止血，抗真菌的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:具有一定的酪氨酸酶抑制作用，保肝利胆效果。
