中文名称:

肾上腺髓质素(22-52 )(人体)

中文同义词:

肾上腺髓质素(22-52 ),人;22-52-肾上腺髓质素;肾上腺髓质素(22-52 )(人体);肾上腺髓质素(22-52 ),人, ≥97% (HPLC);人ADRENOMEDULLIN (22-52)肽;ADRENOMEDULLIN (22-52) (人);痤疮

英文名称:

ADRENOMEDULLIN (22-52) (HUMAN)

英文同义词:

ADRENOMEDULLIN FRAGMENT 22-52 HUMAN;ADRENOMEDULLIN (22-52) (HUMAN);ADRENOMEDULLIN (HUMAN, 22-52);H-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2;TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2;THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2;51: PN: US20050009742 PAGE: 20 claimed sequence;THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2: TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2

CAS号:

159899-65-7

分子式:

C159H252N46O48

分子量:

3575.98

EINECS号:

相关类别:

细胞信号和神经生物学;多肽;细胞生物学;Peptide;Adrenomedullins;Miscellaneous Peptides;Peptides for Cell Biology

Mol文件:

159899-65-7.mol

储存条件 

-20°C

生物活性

Adrenomedullin (AM) (22-52), human，NH2 末端截短的 adrenomedullin 类似物， 为肾上腺髓质素 (adrenomedullin receptor) 受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽 (CGRP) 受体也具有拮抗作用。

靶点

Adrenomedullin receptor, CGRP receptor

体外研究

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist. Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells.

WGK Germany 

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