中文名称:

四氢姜黄素

中文同义词:

TETRAHYDROCUCUMIN 四氢姜黄素;纳米包裹辅酶四氢姜黄素;生物活性四氢姜黄素;水溶性四氢姜黄素;7-双(4-羟基-3-甲氧基苯基)庚烷-3;四氢姜黄素(标准品);1,7-二(3-甲氧基-4-羟基苯基)庚烷-3,5-二酮;四氢姜黄素, 来源于姜黄

英文名称:

Tetrahydrocurcumin

英文同义词:

SabiWhite-;3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-;1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione;Tetrahydrocurcumin;TETRAHYDROCURCUMINOID;Tetrahydrodiferuloylmethane;Aids110028;Aids-110028

CAS号:

36062-04-1

分子式:

C21H24O6

分子量:

372.41

EINECS号:

609-201-3

相关类别:

四氢姜黄素;原料药API;其他原料;标准品-对照品;日化美白原料;香精香料;标准品;Aromatics;中药对照品;对照品;植物提取物;中间体;原料;化妆品原料;对照品-中药对照品;其它酚类;标准品 -中药标准品;标准品，对照品;化工原料;合成材料中间体;医药、农药及染料中间体;Inhibitors;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals

Mol文件:

36062-04-1.mol

熔点 

95-97 ºC

沸点 

564.1±45.0 °C(Predicted)

密度 

1.222

闪点 

196℃

储存条件 

Inert atmosphere,Room Temperature

酸度系数(pKa)

9.12±0.10(Predicted)

形态

powder

BRN 

3485469

InChIKey

LBTVHXHERHESKG-UHFFFAOYSA-N

姜黄根提取物

四氢姜黄素(Tetrahydrocurcumin,简称THC)作为姜黄素在生物体内产生的活跃和主要的代谢产物，由姜科植物姜黄根茎中分离出的姜黄素氢化而来。 四氢姜黄素为天然的姜黄根提取物中主要的美白活性成分，不仅具有最强的酪氨酸酶抑制活性，还具有极好的化学稳定性，而且外观为无味的白色粉末，从而克服了普通姜黄提取物化学不稳定易使皮肤染色的缺陷。普通的姜黄提取物为黄色，化学稳定性差，具有光敏性，在光照下，容易和皮肤发生化学反应而使皮肤染色。

功效与作用

四氢姜黄素为天然功能性美白原料，具有抑制酪氨酸酶的强效活性，美白效果优于我们熟知的熊果苷，能有效抑制氧自由基（oxygen free radicals）的生成并能清除已经形成的自由基，具有明显的抗氧化、抑制黑色素、修复祛斑、抗炎活性、阻断炎症过程等。此外，对自由基的抑制、对各种炎因子脂氧和酶、胶原蛋白酶、透明质酸酶的抑制，体现了四氢姜黄素潜在的抗衰老功效。

安全性

四氢姜黄素添加到化妆品中对人体肌肤无刺激或致敏的副作用，且能安全有效地发挥其作用。

生物活性

Tetrahydrocurcumin 在姜黄 (Curcuma longa) 中发现的一种姜黄素，是由 Curcumin 还原产生的。Tetrahydrocurcumin 抑制 CYP2C9 和 CYP3A4。

靶点

CYP2C9 CYP3A4 Human Endogenous Metabolite Autophagy

CYP2C9

CYP3A4

体外研究

Tetrahydrocurcumin (THC) has a number of attractive properties not shared with Curcumin that may make it superior. Tetrahydrocurcumin inhibited lipoxygenase as low as 1 μM. Tetrahydrocurcumin is tested for its ability to inhibit CYP2C9, CYP3A4, CYP1A2 and CYP2D6. Tetrahydrocurcumin yields dose-dependent inhibition of CYP2C9, and to a lesser extent, CYP3A4. Tetrahydrocurcumin exhibits maximum inhibition of CYP2C9 and CYP3A4 at 50 to 100 μM. Tetrahydrocurcumin does not show a consistent dose-response inhibition of CYP1A2 or CYP2D6 over the range of concentrations tested. In some cases, the percent inhibition exceeds 100%. The effect of Tetrahydrocurcumin on cancer cell viability is measured. Sup-T1 cells, T-cell lymphoblastic lymphoma cells, are treated with Tetrahydrocurcumin to determine its ability to induce growth inhibition using an MTS assay, and the corresponding IC50 values are in the mid-to-high micromolar range.

体内研究

The serum Tetrahydrocurcumin (THC) concentration versus time curve shows that more than one absorption and distribution phase is present. Initially, a rapid absorption phase with an average Tmax of 6.8 μg/mL at 1 h is observed, followed by a short elimination phase. This is followed by two redistributions with two smaller Tetrahydrocurcumin maxima at 6 and 24 h. Both redistribution phases has similar maxima of about 1 μg/mL. The total amount of Tetrahydrocurcumin excrets unchanged in urine was up to 8 μg at 24 h.

化学性质 

类白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于姜黄鳞茎。

用途 

四氢姜黄素具有祛斑美白抗衰老的作用。

WGK Germany 

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