中文名称:

磺胺吡啶

中文同义词:

磺胺吡啶;磺胺吡啶熔点标准物;對胺-N-2-吡啶苯磺醯胺;4-氨基-N-(2-吡啶基)苯磺酰胺;对胺-N-2-吡啶苯磺醯胺;柳氮磺胺吡啶杂质J (EP);柳氮磺吡啶杂质J (EP);柳氮磺胺吡啶EP杂质J

英文名称:

Sulfapyridine

英文同义词:

2-(4-Aminobenzenesulfonamido)pyridine N-2-Pyridylsulfanilide 2-Sulfanilamidopyridine;Sulfapyridine Solution, 100ppm;CTG-B43a;CTG-B45d;HRIHFB2206;Monoclonal Anti-THAP11 antibody produced in mouse;THAP11;Sulfapyridine (Dagenan)

CAS号:

144-83-2

分子式:

C11H11N3O2S

分子量:

249.29

EINECS号:

205-642-7

相关类别:

抗生素;磺胺类;分析标准品;磺胺吡啶;小分子抑制剂;医药原料;法医和兽医标准品;Aromatics Compounds;Pharmaceuticals;Sulfapyridine;SULPHAPYRIDINE;医药 中间体;对照品;中间体;化工产品-有机化工;有机化工原料;其他原料;原料;标准品 -中药标准品;医药原料药 科研原料;中药对照品;Aromatics;Sulfur Selenium Compounds;Intermediates Fine Chemicals

Mol文件:

144-83-2.mol

熔点 

191-193°C

沸点 

473.5±51.0 °C(Predicted)

密度 

1.3220 (rough estimate)

折射率 

1.6740 (estimate)

储存条件 

2-8°C

形态

neat

酸度系数(pKa)

pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)

水溶解性 

<0.1 g/100 mL at 22 ºC

Merck 

14,8938

BRN 

222065

稳定性

Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.

CAS 数据库

144-83-2(CAS DataBase Reference)

NIST化学物质信息

Sulfapyridine(144-83-2)

EPA化学物质信息

Sulfapyridine (144-83-2)

生物活性

Sulfapyridine 是一种磺胺类抗菌药。

体外研究

Sulfapyridine inhibits production of IL-8, chemokine (C-X-C motif) ligand 1 (CXCL1), and monocyte chemotactic protein-1 (MCP-1) in synovial cells of rheumatoid arthritis (RA). MIC range of Sulfapyridine for Y. enterocolitica is 3.1-25 μg/mL and for Salmonella 25-100 μg/mL. Campylobacter jejuni/coli are less susceptible to Sulfapyridine with MIC values ranging from 200 to 800 μg/mL. Shigella and three of five E. coli strains are resistant to 1600 μg/mL of sulfapyridine. Two strains of E. coli are inhibited by 25 μg/mL.

体内研究

Sulfapyridine (1 and 10 μg/kg; i.p.) significantly inhibits systemic allergic reaction induced by compound 48/80 in rats.

化学性质 

黄棕至白色粉末。熔点191-193℃。微溶于水。

用途 

医药中间体。

生产方法 

2-氨基吡啶经缩合、水解而得。

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

22-24/25-36-26

WGK Germany 

2

RTECS号

DA9625000

HazardClass 

IRRITANT

海关编码 

29350010

毒性

LD50 orally in mice: 7.5 mg/g (Wien)