中文同义词:
原花青素B1(95%);原花青素 B1, 来源于葡萄籽;原花青素B1;原矢车菊素B1;原花青素B1(标准品);顺式,反式′′-4,8′′-二-(3,3′,4′,5,7-五羟基黄烷);原花青素(OPC);原花青素B1对照品
英文同义词:
Procyanidin B1, 97%, from Vitis vinifera Linn.;Procyanidin B1 [Epicatechin (4β→8) catechin];PROCYANIDIN B1;CIS,TRANS-4,8-BI-(3,3,4,5,7-PENTAHYDROXYFLAVANE);EPICATECHIN(4B-8)CATECHIN;EPICATECHIN(4BETA->8)CATECHIN;(2R,2R,3R,3S,4R)-2,2-Bis(3,4-dihydroxyphenyl)-4,8-bichroman-3,3,5,5,7,7-hexol;(2R,2R,3R,3S,4β)-3,3,4,4-Tetrahydro-2α,2α-bis(3,4-dihydroxyphenyl)-4,8-bi[2H-1-benzopyran]-3,3,5,5,7,7-hexol
相关类别:
中药对照品;标准品;植物提取物;对照品;植提标准品;花青素标准品;标准品-中药标准品;Catechins Tannins;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品 -中药标准品;天然植物提取物;标准品，对照品;医药、农药及染料中间体
沸点
955.3±65.0 °C(Predicted)
密度
1.705±0.06 g/cm3(Predicted)
酸度系数(pKa)
9.29±0.60(Predicted)
InChIKey
XFZJEEAOWLFHDH-UKWJTHFESA-N
生物活性
Procyanidin B1 是一种多酚类黄酮物质，存在于常见的水果中，能够与 TLR4/MD-2 复合体结合，具有抗炎活性。
体外研究
Procyanidin B1 is a polyphenolic flavonoid isolated from fruits and fruit juices, binds to TLR4/MD-2 complex, and has anti-inflammatory activity. Procyanidin B1 causes cellular toxicity at concentrations >100 μg/mL. Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells. Procyanidin B1 (50-100 µM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 µM, caspase-8 at concentrations of 30, 50, and 100 µM and caspase-9 at concentrations of 10, 30, 50, and 100 µM. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα.
化学性质
淡黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于葡萄籽。
用途
原花青素B1是一种B型原花青素，存在于锡兰肉桂中，具有抗炎，抗氧化，抗肿瘤，保护心血管的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:抗氧活性、抑制肿瘤作用。
