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886992-99-0

中文名称:
886992-99-0
中文同义词:
FAP抑制剂(AC-GLY-BOROPRO)
英文名称:
Ac-Gly-BoroPro
英文同义词:
Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
CAS号:
886992-99-0
分子式:
C8H15BN2O4
分子量:
214.03
EINECS号:
相关类别:
细胞生物学试剂
Mol文件:
886992-99-0.mol
密度 
1.26±0.1 g/cm3(Predicted)
酸度系数(pKa)
9.72±0.20(Predicted)
生物活性
Ac-Gly-BoroPro是选择性的 FAP 抑制剂,Ki 值为23 nM。
靶点
Ki: 23 nM (FAP)
体外研究
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K i =377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.
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CAS    号: 886992-99-0
规       格:10g/20g/100g/1kg
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详细介绍
英文名:
Ac-Gly-BoroPro
外观:
纯度:
请咨询卖家
分子式:
C8H15BN2O4
分子量:
214.03
中文名称:
886992-99-0
中文同义词:
FAP抑制剂(AC-GLY-BOROPRO)
英文名称:
Ac-Gly-BoroPro
英文同义词:
Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
CAS号:
886992-99-0
分子式:
C8H15BN2O4
分子量:
214.03
EINECS号:
相关类别:
细胞生物学试剂
Mol文件:
886992-99-0.mol
密度 
1.26±0.1 g/cm3(Predicted)
酸度系数(pKa)
9.72±0.20(Predicted)
生物活性
Ac-Gly-BoroPro是选择性的 FAP 抑制剂,Ki 值为23 nM。
靶点
Ki: 23 nM (FAP)
体外研究
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K i =377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.
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