中文同义词:
宝藿苷Ⅰ;宝藿苷I,淫羊藿次苷Ⅱ;宝藿苷I;宝藿苷I(标准品);宝藿苷I, 来源于淫羊藿;BAOHUOSIDE I 宝藿苷I 标准品;宝霍苷I((淫羊藿次苷II,脱水淫羊藿苷);BAOHUOSIDE I 宝藿苷I
英文同义词:
3-(α-L-Rhamnopyranosyloxy)-4-methoxy-5,7-dihydroxy-8-prenylflavone;5,7-Dihydroxy-4-methoxy-8-prenyl-3-(α-L-rhamnopyranosyloxy)flavone;Baohuoside-1;Icariin II;Icarisid II;BAOHUOSIDE I; ANHYDROICARITIN; ICARISIDE II;Baohuoside I(Icariside II);baohuoside I
相关类别:
中药对照品;标准品;植物提取物;标准品-中药标准品;分析试剂标准品;植提标准品;chemical reagent;pharmaceutical intermediate;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;对照品;标准物质;植物药;可定制;黄酮;标准品 -中药标准品;分析试剂-指示剂;标准品，对照品;phytochemical
沸点
759.4±60.0 °C(Predicted)
酸度系数(pKa)
6.29±0.40(Predicted)
生物活性
Baohuoside I 是从朝鲜淫羊藿中得到的黄酮类化合物，作为 CXCR4 的抑制剂，能够抑制 CXCR4 的表达，诱导凋亡，具有抗肿瘤活性。
体外研究
Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) suppresses NF-κB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells. Baohuoside I inhibits A549 cell viability, with IC 50 s of 25.1 μM at 24 h, 11.5 μM and 9.6 μM at 48 h and 72 h, respectively. Baohuoside I ((25 μM) suppresses the caspase cascade in A549 cells, elevates ROS levels and activates JNK and p38 MAPK signaling cascade. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC 50 of 4.8 µg/mL at 48 h.
体内研究
Baohuoside I (25 mg/kg) decreases β-catenin protein levels, cyclin D1 and survivin expression in nude mice.
化学性质
黄色针状结晶，溶于甲醇，来源于淫羊藿全草。
用途
药理药效:宝藿苷I对人食管癌细胞Eca-109的抑制作用。
