中文名称:

仙茅苷

中文同义词:

仙茅苷;仙茅甙;仙茅苷, 来源于仙茅;仙茅苷(仙茅甙);仙茅苷(标准品);CURCULIGOSIDE 仙茅苷

英文名称:

CURCULIGOSIDE

英文同义词:

CURCULIGOSIDE;[5-Hydroxy-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl-2,6-dimethoxybenzoate;Curculigoside, 98%, from Curculigo orchioides Gaertn.;CurculigosideA;β-D-Glucopyranoside,2-[[(2,6-diMethoxybenzoyl)oxy]Methyl]-4-hydroxyphenyl;β-D-Glucopyranoside, 2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl;2-[[(2,6-Dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl beta-D-Glucopyranoside

CAS号:

85643-19-2

分子式:

C22H26O11

分子量:

466.44

EINECS号:

相关类别:

对照品;植提标准品;植物提取物;植提;中药对照品;标准品;Miscellaneous Natural Products;对照品,标准品;chemical reagent;pharmaceutical intermediate;phytochemical;标准品-中药标准品;标准品-对照品;标准品，对照品;新品;标准品 -中药标准品;其它酚类;分析试剂-对照品;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract

Mol文件:

85643-19-2.mol

熔点 

158-160 °C(Solv: methanol (67-56-1))

沸点 

734.9±60.0 °C(Predicted)

密度 

1.450±0.06 g/cm3(Predicted)

酸度系数(pKa)

9.70±0.20(Predicted)

概述

仙茅苷有补肾壮阳、益精血、强健筋骨、行血消肿的功效。用于腎虚不足、阳痊遗精、虚瘦内伤、腰脊冷痛、寒虚冷泻、带下、小便频数等临床病症。

生物活性

Curculigoside 是 C. orchioide 中的主要皂苷，具有显着的抗氧化，抗骨质疏松，抗抑郁和神经保护作用。 通过调节 JAK/STAT/NF-κB 信号传导途径，在体内和体外表现出显着的抗关节炎作用。

靶点

JAK; STAT; NF-κB

体外研究

Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability between 1 and 64 µg/ml in MH7A cells. Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group. Cell Viability Assay Cell Line: MH7A cells Concentration: 1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml Incubation Time: 72 hours Result: Had inhibitory effect on MH7A cells. Western Blot Analysis Cell Line: MH7A cells Concentration: 4 μg/ml; 64 μg/ml Incubation Time: 24 hours Result: Downregulated JAK1, JAK3 and STAT3 protein expression.

Cell Line:

MH7A cells

Concentration:

1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml

Incubation Time:

72 hours

Result:

Had inhibitory effect on MH7A cells.

Cell Line:

MH7A cells

Concentration:

4 μg/ml; 64 μg/ml

Incubation Time:

24 hours

Result:

Downregulated JAK1, JAK3 and STAT3 protein expression.

化学性质 

白色颗粒结晶，易溶于甲醇，几乎不溶于乙醚，来源于仙茅。

用途 

仙茅苷具有清除自由基，显著的抗骨质疏松的作用。

用途 

用于含量测定/鉴定/药理实验等。

安全说明 

24/25

海关编码 

29389090