中文名称:

盐酸雷莫司琼

中文同义词:

(-)-(R)-5-[(1-甲基-1H-吲哚-3-基)羰基]-4,5,6,7-四氢-1H-苯并咪唑盐酸盐;盐酸雷莫司琼;盐酸雷莫斯琼;盐酸雷莫司琼 98.5% MIN;雷莫司琼;盐酸雷莫司琼(CAS号:132907-72-3);雷莫司琼盐酸盐;S-盐酸雷莫司琼

英文名称:

Ramosetron hydrochloride

英文同义词:

Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride (1:1);(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride;(1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride;RAMOSETRON HCL;RAMOSETRON HYDROCHLORIDE;(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon;(r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr;(r)-monohydrochlorid

CAS号:

132907-72-3

分子式:

C17H18ClN3O

分子量:

315.8

EINECS号:

相关类别:

原料药;有机原料;医药原料;标准品;中药对照品;医药原料和中间体;Antiemetic;Chiral Reagents;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;API;化工;原料;化学试剂

Mol文件:

132907-72-3.mol

熔点 

244-246°C

比旋光度 

D -42.9° (c 1.02 in methanol)

储存条件 

Hygroscopic, Refrigerator, Under Inert Atmosphere

溶解度 

H2O: soluble20mg/mL, clear

形态

powder

颜色

white to beige

旋光性 (optical activity)

[α]/D -40 to -45°, c = 1 in methanol

InChIKey

XIXYTCLDXQRHJO-RFVHGSKJSA-N

CAS 数据库

132907-72-3(CAS DataBase Reference)

生物活性

Ramosetron Hydrochloride (YM-060)是ramosetron的盐酸盐形式，ramosetron是选择性的serotonin (5-HT) receptor拮抗剂，具有潜在的止吐作用。

靶点

Target Value 5-HT3 receptor (in N1E-15 cells) 0.091 nM(Ki)

Target

Value

5-HT3 receptor (in N1E-15 cells)

0.091 nM(Ki)

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3