中文名称:

三氯卡班

中文同义词:

3,4,4-三氯对称二苯脲,3,4,4-三氯碳酰苯胺1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA;保肤洁;三氯均二苯脲;三氯卡斑防腐剂;N-(4-氯苯基)-N’-(3,4-二氯苯基)脲;三氯卡巴,康洁新;三氯卡巴溶液, 100PPM;3,4,4’-三氯二苯脲

英文名称:

Triclocarban

英文同义词:

TCC;solubacter;Procutene;N-(3,4-DICHLOROPHENYL)-N-(4-CHLOROPHENYL)UREA;N-(4-CHLOROPHENYL)-N-(3,4-DICHLOROPHENYL)-UREA;TRICHLOROCARBANILIDE;TRICLOCARBAN;Carbanilide, 3,4,4-trichloro-

CAS号:

101-20-2

分子式:

C13H9Cl3N2O

分子量:

315.58

EINECS号:

202-924-1

相关类别:

医用原料;化工中间体;标准品;芳烃;有机化合物;有机砌块;通用试剂;其他生化试剂;脲;有机原料;合成材料;Organics;Amines;Aromatics;Intermediates Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Preservative;Pharmaceutical intermediates;有机化工;化工中间体;有机化工原料;日化原料;三氯卡班;原料;中药对照品;日用化工

Mol文件:

101-20-2.mol

熔点 

254-256 °C (lit.)

沸点 

344.2±42.0 °C(Predicted)

密度 

1.5732 (rough estimate)

蒸气压

<0.1 mm Hg ( 25 °C)

折射率 

1.6300 (estimate)

闪点 

150 °C

储存条件 

Refrigerator

溶解度 

methanol: soluble

酸度系数(pKa)

12.77±0.70(Predicted)

形态

neat

颜色

Fine plates

水溶解性 

<0.1 g/100 mL at 26 ºC

Merck 

14,9654

稳定性

Stable. Combustible. Incompatible with strong oxidizing agents strong bases.

InChIKey

ICUTUKXCWQYESQ-UHFFFAOYSA-N

CAS 数据库

101-20-2(CAS DataBase Reference)

NIST化学物质信息

3,4,4-Trichloro carbanilide(101-20-2)

EPA化学物质信息

Triclocarban (101-20-2)

生物活性

Triclocarban是一种常用于个人护理用品中的抗细菌试剂。

靶点

Bacterial

体外研究

Triclocarban (300 nM) potentiates the cytotoxicity of 300 µM H 2 O 2 in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H 2 O 2 , resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.

体内研究

Triclocarban is absorbed significantly from soap used during showering in human subjects and that its C max in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.

化学性质 

白色粉末。

用途 

日用化学品抑菌剂。它具备持续、安全、稳定的杀菌特点，与皮肤有极 好的相容性，并且对革兰氏阳性菌、革兰氏阴性菌、真菌、酵母菌、病毒都具有高效抑杀作用。

用途 

有抑菌作用，广泛用于洗衣粉、肥皂、沐浴露等

危险品标志 

N

危险类别码 

50/53

安全说明 

60-61

危险品运输编号 

UN 3077 9/PG 3

WGK Germany 

2

RTECS号

FE1250000

HazardClass 

9

PackingGroup 

III

海关编码 

38220090

毒害物质数据

101-20-2(Hazardous Substances Data)

毒性

LD50 ipr-mus: 2100 mg/kg LPPTAK 27,306,79