中文同义词:
倍氯米松溶液, 1000PPM;倍氯米松 标准品;9α-氯-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮;9α-氯-16β-甲基孕甾-1,4-二烯-11β,17α,21-三醇-3,20-二酮;倍氯米松;倍氯米松 ≥99%;倍氯美松;倍氯松倍氯美松
英文同义词:
Beclometasone;Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-;9alpha-Chloro-16beta-methylprednisolone;9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9-Chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione;Beclomethasone Solution, 100ppm;9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione;Beclomethasone solution,1000ppm
相关类别:
分析标准品;甾体激素类;甾体激素 (激素，糖皮激素);皮肤类甾体激素;中药对照品;平喘药物;陕西林奈主打产品;Intermediates Fine Chemicals;Pharmaceuticals;Steroids
沸点
600.2±55.0 °C(Predicted)
密度
1.35±0.1 g/cm3(Predicted)
酸度系数(pKa)
12.17±0.70(Predicted)
CAS 数据库
4419-39-0(CAS DataBase Reference)
适应症
用于治疗湿疹、过敏性皮炎、神经性皮炎、扁平苔藓、盘状红斑狼疮、掌跖脓疱病、接触性皮炎、局限性银屑病、皮肤瘙痒症等。丙酸倍氯米松气雾剂用于慢性或过敏性哮喘及过敏性鼻炎等。
生物活性
Beclometasone (Beclomethasone) 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
靶点
Glucocorticoid Receptor
体外研究
An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.
