中文名称:

BRICICLIB

中文同义词:

布瑞西利, >98%;布瑞西利;BRICICLIB (SYNONYMS: ON 014185);化合物BRICICLIB

英文名称:

Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)

英文同义词:

Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);Briciclib,ON-014185;ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate;Briciclib(ON 013105,ON 014185);Briciclib, >98%;ON013105;ON014185;ON-013105;ON-014185

CAS号:

865783-99-9

分子式:

C19H23O10PS

分子量:

474.42

EINECS号:

相关类别:

小分子抑制剂;API

Mol文件:

865783-99-9.mol

储存条件 

Sealed in dry,Room Temperature

生物活性

Briciclib (ON-014185)是ON-013100的水溶性衍生物。ON-013100是一种可与eIF4E结合并抑制其活性的小分子化合物。

靶点

eIF4E

体外研究

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI 50 s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.