中文名称:

辛伐他汀铵盐

中文同义词:

辛伐他汀羟酸铵盐;(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-二甲基丁酰氧基)-1,2,6,7,8,8a-六氢-2,6-二甲基-1-萘基]-3,5-二羟基庚酸铵;辛伐他汀铵盐;辛伐他汀开环铵盐;辛伐他汀羟基酸铵盐;辛伐他汀酸铵盐;辛伐他汀乙酸铵盐;辛伐他汀杂质01(NH3)

英文名称:

Simvastatin ammonium salt

英文同义词:

SIMVASTATIN AMMONIUM SALT;SIMVASTATIN HYDROXY ACID, AMMONIUM SALT;1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a;1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8aR)- (9CI);Simvastatin impurity A;Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyheptanoate;(3R,5R)-7-((1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyheptanoate ammonium salt;Simvastatin acid ammonium salt

CAS号:

139893-43-9

分子式:

C25H43NO6

分子量:

453.61

EINECS号:

1533716-785-6

相关类别:

原料药;血液（造血系统）类药物;医药与生物化工;医药原料;心血管类;医药 心血管类;辛伐他汀杂质B;Inhibitors;Intermediates Fine Chemicals;Metabolites;Pharmaceuticals;HMG-CoA reductase;Chiral Reagents;Heterocycles;Metabolites Impurities;医药原料药-科研原料;168- 辛伐他汀;原料;陕西林奈主打产品

Mol文件:

139893-43-9.mol

熔点 

128-131°C

储存条件 

-20°C

BRN 

4836426

生物活性

Simvastatin ammonium 是一种 simvastatin lactone metabolism 由 CYP3A4/5 在肠壁和肝脏中介导形成的活性代谢产物 (pKa=5.5)。Simvastatin ammonium 可减少吲哚硫酸盐介导的活性氧种类，并调节被 OATP3A1 基因转染的心肌细胞和 HEK293 细胞中 OATP3A1 的表达。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

There is a pH-dependent effect on organic anion transporting polypeptide 3A1 (OATP3A1) uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene. The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells.

危险品标志 

Xi,T

危险类别码 

36/37/38-64-52/53-40-61

安全说明 

26-36-36/37/39-24/25-22-53

WGK Germany 

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