中文名称:

苄噻嗪

中文同义词:

苄硫醚氯噻嗪;苄硫噻嗪;苄噻嗪;苄噻嗪杂质;苯并噻嗪;苄噻嗪 标准品;苄噻嗪BENZTHIAZIDE

英文名称:

BENZTHIAZIDE

英文同义词:

6-Chloro-3-[[(phenylMethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide;((benzylthio)methyl)-3chloro-6dioxyde-1,1sulfonamide-7benzothiadiazine-1,2,;-1,-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide;2h-1,2,4-benzothiadiazine-7-sulfonamide,3-((benzylthio)menthyl)-6-chloro-,1,1;2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl

CAS号:

91-33-8

分子式:

C15H14ClN3O4S3

分子量:

431.94

EINECS号:

202-061-0

相关类别:

小分子抑制剂;利尿药物;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals;Sulfur Selenium Compounds;Heterocyclic Compounds;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Others;S-Containing;AQUATAG

Mol文件:

91-33-8.mol

熔点 

231-232° (U.S. patent); mp 238-239° (Pan)

沸点 

680.6±65.0 °C(Predicted)

密度 

1.4176 (rough estimate)

折射率 

1.6100 (estimate)

酸度系数(pKa)

9.57±0.20(Predicted)

水溶解性 

2.8mg/L(room temperature)

EPA化学物质信息

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)

生物活性

Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂，对 CA9，CA2 和 CA1 的 Ki 值分别为 8.0，8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。

靶点

Ki: 8.0 nM (CA9), 8.8 nM (CA2), 10 nM (CA1)

体外研究

Benzthiazide (0.4, 2, 10 μM) suppresses proliferation of cancer cell under hypoxic conditions in a dose-dependent manner . Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with K i s of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively.

体内研究

Benzthiazide (1, 1.5 mg/100 g BW) causes a marked decrease in urinary calcium excretion and the dissociation of calcium and sodium excretion in hyperprolactinemic rats.

类别

有毒物品

毒性分级

高毒

急性毒性

静脉-大鼠 LD50:422 毫克/公斤; 静脉-小鼠 LD50; 410 毫克/公斤

可燃性危险特性

通风低温干燥; 与库房食可燃; 燃烧产生有毒氮氧化物, 硫氧化物和氯化物烟雾

储运特性

通风低温干燥; 与库房食品原料分开存放

灭火剂

干粉,泡沫,沙土,二氧化碳, 雾状水

危险品标志 

Xn

危险类别码 

42/43

安全说明 

26-36

WGK Germany 

2

RTECS号

DK8400000

毒性

LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (Pan)