美托拉宗
中文名称:
美托拉宗
中文同义词:
7-氯-1,2,3,4-四氢-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺;美托拉宗;美托拉宗(标准品);米托拉腙;甲醋唑胺;美托拉腙;美托拉宗杂质;美托拉索 EP标准品
英文名称:
Metolazone
英文同义词:
s720-22;Zaroxolyn;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-
CAS号:
17560-51-9
分子式:
C16H16ClN3O3S
分子量:
365.83
EINECS号:
241-539-3
相关类别:
中间体;小分子抑制剂;科研试剂;利尿药物;原料;ZAROXOLYN;Other APIs;Organics;Intermediates Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Heterocycles;Sulfur Selenium Compounds
Mol文件:
17560-51-9.mol
熔点
252-254°C
沸点
613.6±65.0 °C(Predicted)
密度
1.2895 (rough estimate)
折射率
1.6100 (estimate)
储存条件
2-8°C
溶解度
DMSO: >5mg/mL
形态
solid
酸度系数(pKa)
pKa 9.7 (Uncertain)
颜色
white
水溶解性
60.3mg/L(25 ºC)
InChIKey
AQCHWTWZEMGIFD-UHFFFAOYSA-N
CAS 数据库
17560-51-9(CAS DataBase Reference)
NIST化学物质信息
Metolazone(17560-51-9)
生物活性
Metolazone (SR 720-22)是一种利尿剂，主要用于治疗充血性心脏衰竭和高血压。
体外研究
Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.
用途
利尿药。
WGK Germany
2
RTECS号
VA1700000
海关编码
2935904000
毒害物质数据
17560-51-9(Hazardous Substances Data)
毒性
LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)
