中文名称:

蒲公英萜酮

中文同义词:

蒲公英赛酮;蒲公英萜酮, 来源于南沙参;蒲公英萜酮

英文名称:

(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one

英文同义词:

(4aS,6aS,6aR,8aR,12aS,14aS,14bS)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4 a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one;D-Friedoolean-14-en-3-one;Taraxera-14-ene-3-one;Taraxerone, 98%, from Adenophora tetraphylla(Thunb.)Fisch;Taraxeron;27-Norolean-14-en-3-one,13-methyl-, (13a)-;Tarxerone;27-Norolean-14-en-3-one, 13-methyl-, (13α)-

CAS号:

514-07-8

分子式:

C30H48O

分子量:

424.7

EINECS号:

相关类别:

标准品;植物提取物;对照品;对照品-中药对照品;标准品 -对照药材;三萜

Mol文件:

514-07-8.mol

熔点 

241-243 °C

沸点 

488.3±44.0 °C(Predicted)

密度 

1.01±0.1 g/cm3(Predicted)

生物活性

Taraxerone 是从景天中分离出来的。Taraxerone 增强乙醇脱氢酶 (ADH) 和乙醛脱氢酶 (ALDH) 活性，EC50 值分别为 512.42 μM 和 500.16 μM。

靶点

EC50: 512.42 μM (ADH); 500.16 μM (ALDH)

体内研究

Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure. Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于淡竹叶、蒲公英。

用途 

用于含量测定/鉴定/药理实验等。

海关编码 

29143990