六氢姜黄素
中文名称:
六氢姜黄素
中文同义词:
六氢姜黄素;六氢姜黄素?, BR;COX-2抑制剂(HEXAHYDROCURCUMIN)
英文名称:
HEXAHYDROCURCUMIN
英文同义词:
HEXAHYDROCURCUMIN;5-Hydroxy-1-(4-hydroxy-3-Methoxycyclohexyl)-7-(4-hydroxy-3-Methoxyphenyl)heptan-3-one;(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone;1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;Hexahydrocurcumin, BR;3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS号:
36062-05-2
分子式:
C21H26O6
分子量:
374.43
EINECS号:
相关类别:
细胞生物学试剂;对照品;中药对照品;标准品;植物提取物;标准品 -对照药材;其它酚类;标准品-对照品;标准品，对照品;对照品
Mol文件:
36062-05-2.mol
熔点
80-82℃
沸点
622.6±55.0 °C(Predicted)
密度
1.226
闪点
218℃
储存条件
Sealed in dry,2-8°C
酸度系数(pKa)
10.02±0.20(Predicted)
形态
neat
BRN
2486876
生物活性
Hexahydrocurcumin 是姜黄素的主要代谢产物之一，是一种选择性的口服活性 COX-2 抑制剂，对 COX-1 无活性。Hexahydrocurcumin 具有抗氧化，抗癌和抗炎的作用。
靶点
COX-2
COX-2
体外研究
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC 50 values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.
Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E 2 (PGE 2 ) in murine macrophages (RAW 264.7) in a concentration-dependent manner.
Cell Viability Assay
Cell Line: HT-29 cells
Concentration: 0 µM, 5 µM, 10 µM, 25 µM
Incubation Time: 24 hours or 48 hours
Result: Significantly decreased the viability of HT-29 colon cancer cells.
RT-PCR
Cell Line: HT-29 cells
Concentration: 25 µM
Incubation Time: 24 hours
Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression.
Western Blot Analysis
Cell Line: HT-29 cells
Concentration: 25 µM
Incubation Time: 24 hours
Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein.
Cell Line:
HT-29 cells
Concentration:
0 µM, 5 µM, 10 µM, 25 µM
Incubation Time:
24 hours or 48 hours
Result:
Significantly decreased the viability of HT-29 colon cancer cells.
Cell Line:
HT-29 cells
Concentration:
25 µM
Incubation Time:
24 hours
Result:
Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression.
Cell Line:
HT-29 cells
Concentration:
25 µM
Incubation Time:
24 hours
Result:
Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein.
体内研究
Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.
Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH)
Dosage: 50 mg/kg
Administration: Oral administration; daily; for 16 weeks
Result: Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.
Animal Model:
Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH)
Dosage:
50 mg/kg
Administration:
Oral administration; daily; for 16 weeks
Result:
Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.
WGK Germany
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