中文名称:

考迈斯托醇

中文同义词:

拟雌内酯, >98%;拟雌内酯;香豆雌酚;ES2细胞增殖抑制剂(COUMESTROL);考迈斯托醇;香豆雌酚(拟雌内酯

英文名称:

COUMESTROL

英文同义词:

cumoesterol;COUMOESTROL;7 12-DIHYDROXYCOUMESTAN 98%;Coumesterol;COUMESTROL(P);Coumestrol, >98%;3,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone;2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98%

CAS号:

479-13-0

分子式:

C15H8O5

分子量:

268.22

EINECS号:

207-525-6

相关类别:

对照品;细胞生物学试剂;植物提取物;木脂素;对照品;Steroids Hormones - 13C 2H;Steroids;Coumarins;Iso-Flavones

Mol文件:

479-13-0.mol

熔点 

≥350 °C(lit.)

沸点 

331.39°C (rough estimate)

密度 

1.2586 (rough estimate)

折射率 

1.7680 (estimate)

储存条件 

Refrigerator

溶解度 

DMSO: soluble

酸度系数(pKa)

8.25±0.20(Predicted)

形态

Light beige solid.

BRN 

266702

CAS 数据库

479-13-0(CAS DataBase Reference)

EPA化学物质信息

Coumestrol (479-13-0)

生物活性

Coumestrol是大豆产品中存在的植物雌激素。可用于癌症，神经障碍和自身免疫疾病的研究。抑制ES2细胞增殖的IC50值为50 μM。

靶点

IC50: 50 μM

体外研究

Coumestrol exerts chemotherapeutic effects via PI3K and ERK1/2 MAPK pathways. Coumestrol inhibits viability and invasion, and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2 and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner. Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.

危险品标志 

Xn

危险类别码 

22-36/37/38

安全说明 

26-36

WGK Germany 

3

RTECS号

DF8077000

F 

10