中文同义词:
款冬素,款冬花素,款冬花酮;款冬素,款冬花素;款冬酮, 来源于款冬花;款冬酮(款冬素,款冬花素,款冬花酮;款冬酮(分析标准品);款冬素;款冬酮(款冬素
英文同义词:
Tussilagone;L 652469;Tussilagone, 98%, from Farfarae Flos;2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-;(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate
相关类别:
分析试剂标准品;标准品;对照品;中药对照品;对照品-中药对照品;倍半萜;标准品，对照品
沸点
471.3±35.0 °C(Predicted)
密度
1.07±0.1 g/cm3 (20 ºC 760 Torr)
生物活性
Tussilagone，Tussilago farfara的主要活性成分，具有抗炎作用。Tussilagone 改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。Tussilagone 抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。
体外研究
Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.
体内研究
Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.
化学性质
白色结晶性粉末，溶于乙醚、氯仿、乙酸乙酯、甲醇，不溶于水，来源于菊科款冬Tussilago farfara的花蕾，千里光 Senecio kleinia Less 根。
用途
款冬酮具有升压，呼吸兴奋作用，提高心肌收缩力，抗血小板聚集作用，钙通道阻断活性，镇咳，祛痰，平喘的作用。
用途
用于含量测定/鉴定/药理实验等
药理药效:有升压、呼吸兴奋作用
