中文名称:

NULL

中文同义词:

MDM2/XIAP抑制剂(MX69);4-(8-((3,4-二甲基苯基)氨基磺酰基)-3A,4,5,9B-四氢-3H-环戊二烯并[C]喹啉-4-基)苯甲酸;化合物MX69

英文名称:

MX-69

英文同义词:

MX-69;CS-2402;MX69 (MX 69;Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-

CAS号:

1005264-47-0

分子式:

C27H26N2O4S

分子量:

474.57

EINECS号:

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

1005264-47-0.mol

生物活性

MX69 是一种 MDM2/XIAP 抑制剂，常用于抗癌研究。

体外研究

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.

体内研究

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.