中文名称:

N-去甲荷叶碱

中文同义词:

N-去甲荷叶碱;酸枣仁碱 IA;原荷叶碱;N-去甲基荷叶碱;N-去甲荷叶碱、酸枣仁碱IA、原荷叶碱;原荷叶碱(N-去甲基荷叶碱);N-去甲荷叶碱标准品;N-去甲荷叶碱对照品

英文名称:

(R)-Nornuciferine

英文同义词:

(6aR)-4,5,6,6a-Tetrahydro-1,2-dimethoxy-7H-dibenzo[de,g]quinoline;(R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-4H-dibenzo[de,g]quinoline;(R)-Nornuciferine;1,2-DiMethoxynoraporphine;Daechualkaloid E;N-DesMethylnuciferine;N-Nornuciferine;Sanjoinine Ia

CAS号:

4846-19-9

分子式:

C18H19NO2

分子量:

281.35

EINECS号:

相关类别:

标准品;植物提取物;分析试剂标准品;对照品-中药对照品;生物碱;标准品 -中药标准品;标准品，对照品;标准品-对照品;对照品

Mol文件:

4846-19-9.mol

熔点 

128-129℃

沸点 

446.4±45.0 °C(Predicted)

密度 

1.163±0.06 g/cm3 (20 ºC 760 Torr)

储存条件 

Keep in dark place,Sealed in dry,2-8°C

酸度系数(pKa)

8.29±0.20(Predicted)

CAS 数据库

4846-19-9

生物活性

N-Nornuciferine是荷叶中的阿朴啡生物碱，可显着抑制 CYP2D6活性， IC50 和 Ki 值分为3.76 和2.34 μM。

靶点

IC50: 3.76 μM (CYP2D6) Ki: 2.34 μM (CYP2D6)

体外研究

The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM.

化学性质 

白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于荷叶。