山楂酸
中文名称:
山楂酸
中文同义词:
山楂酸;山楂叶提取物山楂叶黄酮;山楂酸, 来源于山楂;2Α-羟基齐墩果酸、马斯里酸;山楂酸(2Α-羟基齐墩果酸、马斯里酸);山楂酸,马斯里酸(标准品);MASLINIC ACID 山楂酸;山楂酸MASLINIC ACID
英文名称:
Maslinic acid
英文同义词:
CRATEGOLIC ACID;MASLINIC ACID, 98%;(4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid;CRATEGOLIC ACID (PLEASE CALL);(2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid;CRATEGOLIC ACID(MASLINIC ACID)(P);Maslinic Acid(Crategolic Acid);Maslinic acid, Crataegolic acid
CAS号:
4373-41-5
分子式:
C30H48O4
分子量:
472.7
EINECS号:
相关类别:
标准品-对照品;五环三萜;中药对照品;标准品;植物提取物;对照品;医药中间体;Pentacyclic Triterpenes;Miscellaneous;高纯植物提取物;对照品-中药对照品;三萜;标准品 -中药标准品;标准品，对照品;医药、农药及染料中间体
Mol文件:
4373-41-5.mol
熔点
267～269℃
沸点
570.0±50.0 °C(Predicted)
密度
1.14±0.1 g/cm3(Predicted)
储存条件
2-8°C
溶解度
acetone: soluble1mg/mL, clear, colorless
酸度系数(pKa)
4.63±0.70(Predicted)
形态
powder
颜色
white to off-white
InChIKey
MDZKJHQSJHYOHJ-LLICELPBSA-N
药理作用
山楂酸是一种五环三萜酸，存在于多种天然植物、特别是油橄榄中，对人体具有高安全性。近年来发现山楂酸具有抗癌、抗氧化、抗艾滋病、抗菌、抗糖尿病等多种生物活性，从而引起了人们的研究兴趣。
西班牙格拉纳达大学的科学家发现山楂酸能够抑制丝氨酸蛋白酶，而艾滋病病毒正是利用这种酶将自身从被感染的细胞中向外部释放，扩散至病毒感染者全身。
山楂酸具有抗肿瘤、抗艾滋病病毒作用，能使艾滋病病毒在体内扩散的几率降低80%。
注意事项
本品应在低温干燥保存，特殊产品要在氮气下保存，长时间保存不当含量会有所降低。
生物活性
Maslinic acid 可抑制 NF-κB p65 的 DNA 结合活性, 并消除 IκB-α 磷酸化。
靶点
Target Value
NF-κB
()
Target
Value
NF-κB
()
体外研究
Maslinic acid (MA) inhibits LPS-induced NF-κB translocation to nucleus and phosphorylation of IκB-α. Maslinic acid has also been reported to suppress NF-κB regulated osteoclastogenesis in bone marrow monocytes and inhibit TNF-α-induced NF-κB activity and its downstream genes’ expression in pancreatic cancer cells. To confirm if the anti-inflammatory effects of olive pomace extracts (OPEs) inRAW264.7 cells can be attributed to Maslinic acid, dose-dependence experiments determined the effective concentration of Maslinic acid to be 10-20 μM. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Pretreatment with Maslinic acid significantly reduces the LPS-induced phosphorylation of IκB-α.
体内研究
Paw swelling is alleviated when mice are administered with 200 mg/kg Maslinic acid (MA), significantly suppressing inflammation, compared to the carrageenan induced control group, 4 h after λ-carrageenan injection (0.91±0.51 mm and 1.79±0.4 mm, respectively).
化学性质
易溶于吡啶、氯仿甲醇混合溶剂，微溶于甲醇、乙酸乙酯 来源于红枣、橄榄、山楂等
用途
用于含量测定/鉴定/药理实验等
药理药效:抗肿瘤、抗艾滋病病毒、抗炎、抗菌等作用
安全说明
24/25
WGK Germany
3
海关编码
29181990
