中文名称:

[MET5]脑啡肽

中文同义词:

酪氨酰甘氨酰-甘氨酰-苯丙氨酰-蛋氨酸;蛋氨酸脑啡肽|MET-ENKEPHALIN |[MET5]脑啡肽;MET-ENKEPHALIN肽;蛋氨酸脑啡肽, >99%;蛋氨酸-脑啡呔;[MET5]脑啡肽;蛋氨酸脑啡肽;甲硫氨酸脑啡肽

英文名称:

H-TYR-GLY-GLY-PHE-MET-OH

英文同义词:

porcine,beta-endorphin1-5;[Met5]Enkephalin acetate salt hydrate;methionine enkephalin acetate;N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine;(methionine5)enkephalin;[5-Methionin]Enkephalin, Enkephalin M;[Met5]Enkephalin hydrate acetate salt;l-tyrosylglycylglycyl-l-phenylalanyl-l-methionin

CAS号:

58569-55-4

分子式:

C27H35N5O7S

分子量:

573.66

EINECS号:

261-335-8

相关类别:

多肽;氨基酸及其衍生物;生化试剂;生物化学品;原料药;对照品-中药对照品;Opioid receptor and opioid-like receptor;Peptide;Pepetides;peptides

Mol文件:

58569-55-4.mol

熔点 

174-177 °C

比旋光度 

+31.5°(D/25℃)(c=0.96,メタノール)

沸点 

1052.9±65.0 °C(Predicted)

密度 

1.324±0.06 g/cm3(Predicted)

储存条件 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

酸度系数(pKa)

3.23±0.10(Predicted)

形态

powder

颜色

white

生物活性

Tyr-Gly-Gly-Phe-Met-OH 通过结合阿片样物质受体 (opioid receptor)，可调控人类免疫功能，抑制肿瘤生长。

靶点

Opioid Receptor.

体外研究

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems.

化学性质 

白色或类白色粉末，由5个氨基酸组成，顺序为L-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸。

用途 

用于生化研究，神经生物学研究。

生产方法 

以L-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸为原料，先将氨基酸中有侧链的氨基酸的侧链按其特性分别用保护剂保护后，在多肽缩合剂存在下进行缩合反应，然后除去保护剂纯化制得。

安全说明 

22-24/25

WGK Germany 

3

F 

3-10-21