中文同义词:
色氨酸 杂质C;色氨酸EP杂质C;L-犬尿氨酸水合物 10G;L-犬尿酸水合物;(S)-2-氨基-4-(2-氨基苯基)-4-氧代丁酸;L-犬脲氨酸;L-犬尿氨酸(标准品);L-犬尿氨酸水合物
英文同义词:
Tryptophan Impurity 3（Tryptophan EP Impurity C）;JACS-2922-83-0;L-2-AMINO-3-(2-AMINOBENZOYL)PROPIONIC ACID;L-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID;L-KYNURENINE;L-kynurenine free base;β-Anthraniloyl-L-alanine;β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
相关类别:
化学连接;Amino Acids;Amino Acids;Biochemistry;non-Proteinorganic Amino Acids
沸点
466.6±45.0 °C(Predicted)
密度
1.343±0.06 g/cm3(Predicted)
储存条件
Keep in dark place,Inert atmosphere,2-8°C
酸度系数(pKa)
2.21±0.23(Predicted)
InChIKey
YGPSJZOEDVAXAB-QMMMGPOBSA-N
CAS 数据库
2922-83-0(CAS DataBase Reference)
生物活性
L-Kynurenine ((S)-Kynurenine)是一种 aryl hydrocarbon receptor (AhR) 激动剂。 L-Kynurenine是氨基酸L-色氨酸的代谢产物和色氨酸代谢途径的中心化合物，可用于生产烟酸（niacin）。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells.
体内研究
Kynurenine dilates arteries from rats as well as humans via Kv7 channels in the vascular smooth muscle. In rats, this tryptophan metabolite causes hypotension, which is partly counteracted by Kv7 channel inhibition. L-kynurenine administered 1 h before the hypoxia-ischemia shows a dose-dependent significant neuroprotective effect, with complete protection at a dose of 300 mg/kg. The induction of c-fos immunoreactivity in cerebral cortex is also blocked by this dose of L-kynurenine.
