中文名称:

JW-55

中文同义词:

N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺;N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55);Β-CATENIN抑制剂(JW 55);N-(4-((4-(4-甲氧基苯基)四氢-2H-吡喃-4-基)甲基氨基甲酰基)苯基)呋喃-2-甲酰胺

英文名称:

JW55

英文同义词:

JW55;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW 55, >=98%;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;Tankyrase1/2 Inhibitor IV, JW55

CAS号:

664993-53-7

分子式:

C25H26N2O5

分子量:

434.48

EINECS号:

相关类别:

细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;Inhibitors;Amines;Aromatics;Heterocycles;Intermediates Fine Chemicals;Pharmaceuticals

Mol文件:

664993-53-7.mol

沸点 

572.6±50.0 °C(Predicted)

密度 

1.235±0.06 g/cm3(Predicted)

储存条件 

Inert atmosphere,2-8°C

溶解度 

DMSO: soluble15mg/mL, clear

形态

powder

酸度系数(pKa)

12.41±0.70(Predicted)

颜色

white to beige

生物活性

JW55是一种有效的、选择性经典Wnt信号通路抑制剂，通过抑制TNKS1/2的PARP区域发挥作用。

靶点

Target Value Wnt ()

Target

Value

Wnt ()

体外研究

JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells.

体内研究

JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice.

WGK Germany 

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